Fig. 8. At 90 days of age the higher systolic pressure and the accelerated heart rate persist at the same levels: Losartan and Valproate decrease systolic arterial pressure, but not heart rate. (A) Systolic arterial pressure (SAP). (B) Heart rate (HR). Empty bars, normonourished control rats (C); black bars, malnourished rats (M). Pharmacological treatments: panels C, E and G (SAP); panels D, F and H (HR). Vertical dashed lines separate normonourished and malnourished groups. The left sections correspond to normonourished rats; the right sections correspond to malnourished rats. Abbreviations of the groups are indicated on the abscissae, according to the nutritional status and the timeline of pharmacological interventions with Losartan, Valproate or a combination of both drugs, as described in the text and in Supplementary Table 1. The data are mean ± SEM (n = 10-20). Differences were assessed by Student's t-test. The p values are indicated within the panels.